Identification of GLP-1 analog oligomeric states using SEC-MALS

Explore the use of size-exclusion chromatography coupled with multi-angle light scattering (SEC-MALS) to characterize glucagon-like peptide-1 analogs (GLP-1a) like liraglutide and semaglutide. By analyzing monomers, oligomers, and aggregates under native and denaturing conditions, SEC-MALS ensures proper formulation, reducing undesirable high-order structures to enhance the safety and efficacy of GLP-1a therapeutics.