Improved peak shape and lower LOQs in pesticide analysis

In this application note from Agilent Technologies, explore the use of an Agilent 1260 Infinity II Hybrid Multisampler in Agilent Feed Injection mode for the multiresidue LC/MS analysis of polar pesticides dissolved in strong eluting organic solvent. The 1260 Infinity II Hybrid Multisampler is used to infuse the sample at various feed speeds, mitigating solvent effects and trapping and enriching the polar compounds on the column. This technique eliminates breakthrough and provides better peak shapes, which improves detection, quantification, and fully automated peak integration. A typical multiresidue method where this technique can be applied is the analysis of pesticides extracted from fruits and vegetables using pure acetonitrile in QuEChERS sample preparation.