Improving Compound Extraction Efficiency Using the Precellys24

Determining the skin penetration profile of active pharmaceutical ingredients present in creams, gels, lotions, and ointments is an important aspect of preclinical dermatological research and key to optimizing the selection of formulation prototypes. The aim of this study is to evaluate the use of a high throughput, automated method versus a traditional liquid extraction (LE) technique to extract compounds of interest from skin tissues in a more efficient manner for downstream LC-MS/MS analysis.