In Vivo Quantification of Integrin-Targeted and Protease-Activated Imaging Agents in Response to Anti-Angiogenic Therapy using Quantitative Fluorescence Tomography

The aim of this study was to simultaneously and non-invasively image and quantify signal of αvβ3 receptor binding and the signal of a cathepsin-activatable imaging agent using a specific, targeted near-infrared (NIR) fluorescence agent and Fluorescence Molecular Tomography – or FMTTM (FMT 2500TM Quantitative Tomography System, PerkinElmer).