Incorporating the Extracellular Matrix: New Opportunities in Cancer Research

Read this application note from amsbio to learn about the ECM proteins most relevant to cancer research. Self-organization models are described, with particular focus on the use of reconstituted basement membrane to study epithelial behavior. The broader application of ECM substrates is also explored in studying motility, in the context of adhesion, migration and invasion assays. Additional use of ECM products in vivo is discussed as a method to enhance the use of animal models.