Interrogating Chromatin Modifying Enzymes Using Transcreener® Assays

Biochemical HTS assays are a critical component of epigenetic drug discovery programs focused on the enzymes that catalyze posttranslational chromatin modifications. Transcreener is a highly validated, homogenous HTS platform that relies on fluorescence-based detection of nucleotides, including ADP and AMP. The following poster describes how these Transcreener assays allow accurate and robust initial velocity detection of four different types of chromatin modifying enzymes: methyltransferases, acetyltransferases, kinases, and SUMO ligases.