Iodine in a Pharmaceutical Product: Applying Combustion Ion Chromatography with Inline Matrix Elimination

Iodine content in numerous iodinated X-ray contrast media (ICM) is approximately 50%, and is best determined by Combustion IC. For complete absorption of the iodine, high amounts of H₂O₂ (1000 mg/L) are required. Similarly, concentration of the internal standard should be 50 mg/L. The water content in the ICM is determined via Metrohm’s Karl Fischer oven method and has to be considered in the final calculation.