Ion Chromatography Assay for Chloride and Sulfate in Adenosine

This application note describes the development of fast and robust ion chromatography (IC)-based method for the determination of chloride and sulfate in adenosine—a method that can replace the USP monograph’s existing turbidity-based assays of these compounds. The robustness of the method was studied by determining the response of a standard solution containing 1.4 and 5 ppm chloride and sulfate, respectively, under typical variations of analytical conditions.