Is Retention Time Precision Only Affected by the LC Pump?

Historically, the retention time precision of a liquid chromatography (LC) system was attributed to the pump of that instrument. This poster illustrates that not only the pump is of importance but also the autosampler and detector technology. The retention time precision of a Thermo Scientific™ Vanquish™ UHPLC instrument, and the pump performance at demanding physical conditions were evaluated. The effect of a sample pre-compression and assessed the importance of sufficiently high data collection rates were also investigated.