Label-Free SPR Binding Assays in Lead Finding for an Orphan Nuclear Receptor

Orphan receptors provide opportunities to characterize novel signal transduction pathways and new potential drug targets This application poster applies Surface plasmon resonance (SPR), thermal stability and mass spectrometry (MS) to an NR target. Through this target approach an X-Ray structure of this orphan NR could be obtained with one of the compound discovered in this process.