LC-HRMS analysis of the antisense oligonucleotide Mipomersen (Kynamro)

In this application note, YMC Europe demonstrates the use of Mipomersen as a model for the analysis of antisense oligonucleotides (ASOs) using LC-HRMS, utilizing a YMC-Triart C8 metal-free column which is an excellent choice for oligonucleotide analysis ensuring symmetric peaks, high sensitivity, and no carry-over effects.