LC-MS/MS Analysis in Immunosuppressant Drug Research using EVOQ™ Elite LC-MS/MS System

This application note describes an LC-MS/MS research method for the analysis of four immunosuppressant drugs, namely, tacrolimus, sirolimus, everolimus, and cyclosporine A, in the plasma. The method is sensitive to detect 0.5 ng/mL level of tacrolimus, sirolimus, everolimus, and 10 ng/mL of cyclosporine A.