LC-MS/MS toxicology workflow on the new Orbitrap Exploris 120 mass spectrometer for screening, quantitation, and confirmation of drugs

In this application note, Thermo Fisher Scientific presents a targeted screening and quantitation method for a wide range of drugs of abuse and toxins using the Thermo Scientific^™ Tox Explorer^™ Collection. This workflow utilizes the high-resolution, accurate-mass Thermo Scientific^™ Orbitrap^™ Exploris^™ 120 mass spectrometer. The method involves screening identified compounds against a comprehensive HRAM MS/MS spectral library and a compound database containing molecular formula, exact mass, retention times, and fragment ions.