<i>In Vitro</i> Modeling of Cytokine-Drug Interactions Using Micropatterned Co-Cultures Of Primary Hepatocytes and Kupffer Macrophages

Better predictive models for iDILI would enable the preclinical elimination of drug candidates with hepatotoxic liabilities. This poster describes a method in which HepatoPac co-cultures are supplemented with primary Kupffer macrophages for use in evaluating cytokine- drug interactions. Drug- induced stresses may interact with cytokine signaling to cause hepatotoxciity.