LVP Application Performance of Millipore Express SHC and SHF 0.2 µm Membranes

Large volume parenterals (LVPs) are intravenous fluid products provided to patients at >100 mL doses. Batch sizes for LVP applications are in the tens of thousands of liters. Sugars are the predominant LVP solution constituent. Given the large volume of fluids to be filtered and potentially high particle loading on the filter, high flow rates and high throughput are necessary for efficient, economical filtration. Given these performance requirements, several Millipore and competitive sterilizing-grade filters were tested for throughput using LVP model streams. For this study, glucose was tested in a range of concentrations commonly found in LVP formulations.