MALDI-TOF MS Analysis of Nanotrap Enriched Low Molecular Weight Proteins from Human Serum

Biomarkers are often masked by high abundant proteins or may be susceptible to proteolysis. This application note from Shimadzu Scientific Instruments illustrates the ability to enrich low abundant, low molecular weight proteins directly from serum while excluding high molecular weight proteins. The ability to differentially trap proteins based on bait chemistry is also examined.