Managing Sample Volume for Micro Bioreactor Analytics

Many traditional analyzers are not designed for use with micro scale bioreactors, so managing the culture volume when running ambr15 experiments requires some planning. This technical note presents several methods that users currently employ to acquire necessary off-line data when running the ambr15 system. These include the use of low volume analyzers, reducing sample frequency, prioritization of assays, dilution of samples, and sampling a single vessel among replicates.