Matrix-free Small Molecule Analyses Using REDIchip™ on a MALDI Platform

Standard MALDI techniques are not ideal for small molecule analysis and detection in the lower spectral mass region (m/z < 1000). MS signals for small molecules are often masked or suppressed due to matrix interference. REDIchips (Resonance-Enhanced Desorption Ionization) are sample target plates with nanopost array (NAPA) surfaces for matrix-free laser desorption ionization of small molecules. This application note demonstrates how REDIchips eliminate the need for matrix application on your samples, enabling effective detection of small molecules and mixtures on your MALDI platform.