miRNA Biomarker Discovery – Overcoming Limiting Sample Material

Often the most valuable and informative samples — such as laser-captured samples, circulating tumor cells, or extracellular miRNA in body fluids — are the hardest to obtain in amounts sufficient for detailed miRNome profiling. This white paper presents an integrated, PCR-based system that reduces the amount of sample required for full miRNome profiling by several orders of magnitude and provides unparalleled reproducibility and precision. This advance enables detailed miRNA analysis on the smallest of samples and opens up new possibilities for biomarker development.