Multiomic 6-base data from cfDNA enhances the performance of liquid biopsy classifiers

Early cancer detection has the potential to significantly improve treatment outcomes and survival rates. Explore the results of a study that investigated the roles of 5- methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA). Using duet evoC for whole genome 6-base sequencing, cfDNA from 37 treatment-naive CRC patients and 32 healthy controls was analyzed.