Multivariate Curve Estimation of Radiotracer Kinetics by Cerenkov Radiation Imaging in Small Animals

This application note from Caliper LS describes optical imaging methods for determining radiotracer distribution. Detection of radiotracer distribution in preclinical animal models has traditionally required use of costly PET or SPECT scanners, often accompanied by a CT scanner for anatomical reference. The detection of Cerenkov radiation emitted by charged radionucleotide decay products has recently emerged as a promising method to track radiotracer distribution in vivo.