ResourceLife Sciences
Novel Fc Effector Function Reporter Bioassays from Promega for Development of Therapeutic Antibodies
10 Apr 2016This poster discusses the development of a suite of Fc receptor-specific reporter bioassays to interrogate antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) mechanisms of action. Drug developers and regulatory authorities recognize ADCC and ADCP as important mechanisms of action of therapeutic antibodies (Abs). In qualification studies, the Fc effector reporter bioassays exhibit excellent specificity, accuracy, precision, and linearity enabling their use in Ab characterization, optimization, and potency determination.