Novel GPR39 Agonsits: Correlation of Binding Affinity Using Label-Free Back-Scattering Interfreometry with Potency in Functional Assays.

This poster describes the application of Back Scattering Interfreometry (BSI) to the characterization of small molecule ligand binding to human GPR39 overexpressed in crude membrane fractions in free solution. Results from screening representatives from multiple novel GPR39 agonist series is presented, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds.