Novel near Infrared Agent for Non-Invasive Imaging and Quantification of Glomerular Filtration Rate in Mice

The measurement of glomerular filtration rate (GFR) is the gold standard in kidney function assessment and is used to determine progression of kidney disease and drug‐induced kidney toxicity.
This application note presents a study which provides evidence for the utility of GFR-Vivo 680, in combination with FMT imaging, in the non-invasive quantification of glomerular filtration rate (GFR). Statistically significant changes in GFR upon uninephrectomy and cyclosporine A toxicity were easily detected. Heart tomography of GFR-Vivo 680 fluorescence should provide a robust approach to generate consistent GFR measurements in models of kidney disease, dysfunction, and drug toxicity.