Oligonucleotide characterization using μPAC™ nanoLC C18 columns in ion-pairing reversed phase liquid chromatography (IPRP-LC) mode

In this application note, the resolving power of micro Pillar Array Columns (μPAC™) for closely related oligonucleotide sequences is demonstrated using an oligo-T ladder and benchmarked versus state-of-the-art packed bed columns.