Optimer-targeted gene silencing in primary fibrotic hepatic stellate cells

Optimer® is a discovery platform for next-generation affinity ligands. Target specific Optimer® binders are isolated from a diverse library (1014 sequences) through an in vitro discovery process, tailored to produce reagents for use in targeted delivery of gene therapy payloads. This resource outlines a study that shows how Optimer®-siRNA conjugates effectively silence target genes in fibrotic liver cells for the development of new precision therapies for liver disease.