Optimization of In-Source Adduct Formation for the Analysis of Digoxin in Human Plasma by LC-MS/MS

Digoxin is a P-glycoprotein substrate commonly prescribed to treat cardiac arrest and arrhythmias. This poster presents an LC-MS/MS method for sensitive quantification of digoxin in human plasma that could potentially be applied in drug-drug interaction studies, where the levels of digoxin observed in plasma samples may deviate significantly from expected therapeutic levels.