Optimization of Neuronal Cultures Derived from Human Induced Pluripotent Stem Cells for High Throughput Assays of Synaptic Function

This poster describes the use of a previously high-throughput screening technology, termed the MANTRA™ (Multiwell Automated NeuroTRansmission Assay) system, for identifying modulators of synaptic function in rodent primary neuronal cultures. The study described employs the MANTRA system in an integrated drug discovery platform that targets synaptic transmission at multiple levels.