Organic Acids besides Standard Anions in Monoethylene Glycol (MEG) Applying a Dose-on Gradient

The separation of short-chain organic acids from fluoride and chloride requires diluted eluents. These weak eluents, however, induce long retention times for divalent anions. Adding a stronger eluent later in the run by use of a Dose-in Gradient makes these anions elute sooner. An advantage of the Dose-in Gradient is that it does not require multiple high-pressure pumps or proportioning valves.