Overcoming Optical Focus Issues in Handheld Raman Systems for Analysis of Pharmaceutical Drug Formulations

This application note describes the advantages of using the optical focus technique – the Orbital-Raster-Scan (ORS) – in Metrohm’s handheld Raman system “Mira” over traditional techniques. The experiments demonstrated the benefits of using ORS technique to perform identification and quantification of drug formulations. The reproducibility of Raman signals from target active pharmaceutical ingredients (APIs) in the effervescent cold medicine was increased, the analysis time was faster and the matching power of known drug formulations to library spectra was improved and more consistent.