Perfusion CHO Cell Culture in a BioBLU® 5p Single-use Packed-Bed Vessel

The market for secreted recombinant protein therapeutics, including blockbuster drugs in the form of humanized monoclonal antibodies (hmAbs), has become a multi-billion dollar industry with the expectation of continued growth. One of the most cost-effective methods for the production of secreted proteins is the packed-bed vessel operated under perfusion conditions. This poster provides an example of using a BioBLU 5p packed-bed single-use vessel to conduct Chinese hamster ovary cell (CHO) perfusion culture producing a secreted hmAb.