Photochemical functionalisation of peptides and proteins

Peptide-based therapeutics are traditionally synthesized using solid-phase peptide synthesis (SPPS), however due to short half-lives, poor bio-availability and difficulties in scaling-up for high-volume demands, peptide-based therapeutics have shown limitations in the world of drug discovery.

Vapourtec has produced an alternative synthesis technique for proteins, including a C-terminal α-amide, that has been demonstrated to successfully achieve gram-scale synthesis using the Vapourtec-R Series flow system equipped with a UV-150 photochemical reactor module. Discover how Novartis was able to utilize this technology to efficiently synthesise a GLP-1R agonist on a small scale and an analogue of PYY on a larger scale.