Pre-clinical efficacy services for drug development using PDX and humanized NSG

In this application note, The Jackson Laboratory introduces a simplified approach to compound efficacy studies. The NSG™ PDX mice are highlighted as an excellent, fast, and cost-effective platform for simulating trials, assessing multiple drugs alone or in combination, and generating predictive data. The note emphasizes the relevance and translatability of PDX models in studying human cancer biology, providing tumor models at lower passages for improved accuracy in reflecting clinical samples.