Preparation of Pyrazoles from Acetophenones in Flow using a 2–Stage Reaction

This Application Note describes an efficient synthesis of a library of pyrazoles developed by chemists at GalChimia that invokes a 2 step process whereby a starting acetophenone is first condensed with DMADMF to form an intermediate enaminone, followed by a second condensation with hydrazine to generate the desired pyrazoles.