Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas

Bladder cancer compromises a broad spectrum of tumors that includes transitional cell carcinomas (TCCs), squamous cell carcinomas (SCCs), adenocarcinomas, small cell carcinomas, and leiomyomas. To achieve a more reliable and objective classification of bladder SCCs that may eventually pave the way for studies of the molecular mechanisms underlying progression, this technical note explores the possibility of using proteome expression profiles of these lesions as fingerprints to identify tumor subtypes and to define their grade of atypia.