QCM-D as a Powerful Real-Time Screening Tool for Protein Adsorption onto Glass and Plastic Surfaces

Plastic and glass materials are continuously used in protein biotechnology applications. Proteins have a tendency to passively adsorb to such surfaces via hydrophobic interactions, a phenomenon that has to be minimized or prevented in, for example, large-scale recombinant protein production. In such processes, extremely high protein concentrations, ranging from 40-100 mg/ml, are normally used. In this application note, QCM-D is used as a real-time screening tool for protein adsorption onto PVDF and borosilicate.