Quantification of Benzodiazepines in Human Plasma or Serum by Liquid Chromatography Tandem Mass Spectrometry for Clinical Research

In this application note, a clinical research analytical method for the quantification of 35 benzodiazepines in human plasma or serum is reported. The panel includes :

3-hydroxybromazepam, 7-aminoclonazepam, 7-aminoflunitrazepam, 7-aminonitrazepam, α-OH-alprazolam, α-OH-midazolam, α-OH-triazolam, alprazolam, bromazepam, chlordiazepoxide, clobazam, clonazepam, demoxepam, desalkylflurazepam, desmethylflunitrazepam, diazepam, estazolam, flunitrazepam, flurazepam, lorazepam, lormetazepam, medazepam, midazolam, nitrazepam, norclobazam, nordiazepam, oxazepam, prazepam, temazepam, tetrazepam, trazodone, triazolam, zaleplon, zolpidem, and zopiclone.