Quantitative analysis of 16 cannabinoids with complete baseline separation of Δ8 and Δ9-THC utilizing the Triple Quad LCMS-8050

As interest increases in analyzing inherently complex cannabis and hemp-based products, there is growing demand for the analytical benefits of LC-MS/MS such as higher sensitivity, selectivity, and resolution for the determination of cannabinoids. This application note demonstrates a rapid, selective and robust method for the detection of various cannabinoids by using the Shimadzu LCMS-8050. This method demonstrates the ability of the Nexera X2 UHPLC and LCMS-8050 mass spectrometer to enable simultaneous, accurate measurement of many of the cannabinoids of interest.