Quantitative Clonal Barcode Analysis for the Identification of Key Drivers of Disease Progression and Drug Resistance

The ability to label and trace individual cells is a powerful experimental approach in many research areas, including stem cell biology, evolution and cancer biology. Labeling of individual cancer cells with different engineered or natural driver lesions and modeling of in vivo or in vitro clonal expansion can facilitate discovery of genetic determinants of increased pathogenicity, cancer progression or drug resistance.