Quantitative LC-MS/MS analysis of Sulfonamides in Honey using Advance UHPLC-EVOQ™ Elite LC-MS/MS system

This application note describes a simple, robust and effective LC-MS/MS method operated in multiple reaction monitoring (MRM) mode for simultaneous estimation of “Sulfonamide Drugs” in food grade honey with easy and minimal sample preparation. The method was found to be linear and repeatable with regression (R)² of > 0.996 and relative standard deviation of <12% for all nine Sulfonamides under study.