Rapid Assessment of Size Changes Using the Scepter™ Cell Counter can be Predictive of Cell Death

The process of programmed cell death or apoptosis is an essential component in many biological processes and is therefore the focus of much research. Initial studies revealed that reduction in cell volume was an early morphological change during apoptosis. Recent studies have shown that this cell shrinkage is not simply a passive consequence of other apoptotic events, but is a key driver of apoptotic signaling, mediated by the cell’s machinery for homeostatic regulation. In this application note read how the Scepter™ handheld, automated cell counter can be used to measure cell size as an indicator of apoptosis.