Rapid Determination of Hesperidin in Orange Peel Using Accelerated Solvent Extraction and UHPLC

Hesperidin is an antioxidant that enhances the action of vitamin C to lower cholesterol levels. The Pharmacopoeia of the Peoples Republic of China (PPRC) 2010 recommends its extraction from fruits with a method that is both time- and solvent-consuming. The aim of this note is to develop a more efficient and cost-effective method to determine hesperidin in orange peel and other citrus fruits.