Rapid, Reliable Metabolite Ratio Evaluation for MIST Assessments in Drug Discovery and Preclinical Studies

To comply with U.S. FDA guidelines regarding the safety of drug metabolites in human plasma, there is a need to rapidly evaluate and accurately quantify multiple, diverse drug candidates and metabolites in a discovery or preclinical setting. Methodologies that are generic, fast, and robust are featured in this application note from Waters using Ostro 96-well plates and XBridge BEH XP 2.5 µm columns for accurate metabolite ratio determination.