Rapid Separation of Ibuprofen, Ibuprofen- Related Compound C, and Valerophenone Using Advanced UHPLC and Sub-2 μm Solid Core Column Technologies

This application note demonstrates the advantages of using the Thermo Scientific™ Accucore™ Vanquish™ C18+ 1.5 μm UHPLC column and the Thermo Scientific Vanquish UHPLC system for the separation of ibuprofen, ibuprofen-related compound C, and valerophenone. The advanced capabilities of the Vanquish UHPLC system allow the Accucore Vanquish UHPLC columns to be operated at higher flow rates that enable development of rapid analytical methods while maintaining performance.