Reducing Variability in Small Molecule Screening and Kinetics Applications

Minimising the variability of background signals is a key parameter to the sucess of demanding applications such as small molecule analysis. By reducing the background variability, smaller positive signals can successfully be resolved, providing an increase in assay sensitivity. This application note demonstrates the use of a reference biosensor with biotinylated streptavidin for increasing signalto-noise levels, thereby improving the detection of small molecules, including fragments.