Reliable single cell cloning with advanced microfluidic dispensing

With the inherent need for single cells in the production of biologics, the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) has stipulated that biotherapeutics are derived from a single clonal source. This is to ensure consistency and quality of production and to reduce population heterogeneity. In this application note, Sphere Fluidics presents the Cyto-Mine^® Single Cell Analysis System – specifically designed to ensure monoclonality via accurate and reliable single cell dispensing. The next-generation platform provides automated, accurate, cost-effective high-throughput screening with gentle processing and reduced contamination.