Reproducible Burst Release from Time-Delayed Tablets Independent of pH and Hydrodynamic Agitation

It has long been recognized that agitation rate has a profound effect on tablet disintegration and drug dissolution, and the changing hydrodynamic environment of the gastrointestinal tract (GIT) is thought to contribute to the variability of solid oral dosage form performance in vivo. The experiment described in this poster determines robustness of the lag time before drug release in vitro for a press coated time-delayed tablet formulation, designed to perform independently of the variable local hydrodynamic environment of the GIT.