Robustness characterization of a quantitative whole blood assay using PaperSpray technology for clinical research

The analytical technique when a sample is spotted onto a strip of paper and is extracted and ionized directly at the ion source of the mass spectrometer is described as PaperSpray mass spectrometry. This method of technology provides significant benefits for high-throughput applications because analysis times are short, and little to no sample preparation is required. In this application note, Thermo Fisher Scientific describes a method for quantitative and robust analysis of EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine), an opioid metabolite, in human whole blood for clinical research using the VeriSpray™ Paper Spray ion source coupled with a TSQ Quantis™ mass spectrometer.