RT-MALS end-point determination of a polysaccharide depolymerization process

Current methods to monitor molar mass during polysaccharide production employ off-line SEC-MALS analysis, during which a single run can take up to 30 minutes. With a typical depolymerization time of about 90 minutes, off-line analytics cannot provide timely feedback on reaching the endpoint. In this application note, Wyatt Technology demonstrates how real-time multi-angle light scattering (RT-MALS) fills this need and ensures that the process ends as soon as the endpoint criterion is achieved.