Screening for Compounds that Induce Myeloid Progenitor Cell Differentiation

This report describes a high throughput screening method based on the HyperCyt high capacity flow cytometry platform for identifying biologically relevant compounds that overcome differentiation arrest in primary myeloid progenitor cells. By incorporating this platform into the screen, compounds that stimulated differentiation of stem cells while eliminating compounds that exhibited toxic effects on the cells were easily differentiated.